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Tijdsperceptie en prospectief geheugen bij de ziekte van Parkinson

By Y. Daemen


Patients with Parkinson’s disease exhibit deficits in perception of time, which are related to dysfunction of dopaminergic systems in the basal ganglia. A depletion of dopamine in the basal ganglia is thought to slow down the rate of an ‘internal clock’. According to the ‘scalar timing theory’ this would cause an underestimation of time on a time estimation task and an overestimation of time on a time production task. For a time reproduction task this slower rate isn’t supposed to cause an effect. Also in prospective memory timing processes seem necessary to carry out an action at the right moment. The aim of the present study was to investigate whether patients with Parkinson’s disease show a pattern on time perception tasks that fits a lower frequency of the internal clock. The second goal was to explore whether the assumed slower rate also has an effect on the timing components which are important in prospective memory. We compared 9 medicated patients with Parkinson’s disease with 7 healthy control subjects on a time estimation, production and reproduction task and on a prospective memory task with an event-based as well as an time-based element. For the reproduction task no group differences were found. For the estimation and production task a pattern was found that fits a faster rate of an internal clock, in contrast to the assumed slower rate. A possible explanation for this pattern is the dopaminergic medication that was used, which might have accelerated the rate of the internal clock abnormally. For the prospective memory task no group differences were found, which might be a result of the complexity of the task and the small group size

Topics: Sociale Wetenschappen, Parkinson, tijdsperceptie, prospectief, geheugen, dopamine, interne, klok
Year: 2008
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