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Reduction of ferricytochrome c, methemoglobin and metmyoglobin by hydroxyl and alcohol radicals

By J.W. van Leeuwen, J. Tromp and H. Nauta


We have studied the reaction of ferricytochrome c, methemoglobin and metmyoglobin with OH and alcohol radicals (methanol, ethanol, ethylene glycol and glycerol). These radicals can be divided into three groups: \ud \ud 1. 1.|The OH radicals which reduce the ferricytochrome c with a yield of (30 ± 10)% and methemoglobin with a yield of (40 ± 10)%. They do not reduce metmyoglobin. The reduction is not a normal bimolecular reaction but is most probably an intramolecular electron transfer of a protein radical.\ud \ud 2. 2.|Methanol and ethanol radicals which reduce all three hemoproteins with a yield of (100 ± 5)%. This reduction is a normal bimolecular reaction.\ud \ud 3. 3.|Glycerol radicals which do not reduce the ferrihemoproteins under our experimental conditions. Ethylene glycol radicals do not reduce ferricytochrome c and metmyoglobin but they do reduce methemoglobin with a yield of (30 ± 10)%

Topics: Natuur- en Sterrenkunde, cytochrome c, hemoglobin, myoglobin, hydroxyl radical, alcohol radical, pulse radiolysis
Year: 1979
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