Diphosphatidylglycerol (cardiolipin) biosynthesis from CDP-diglyceride and
sn-glycerol-3-phosphate has been demonstrated in a preparation of mitochondria from
rat liver in a reaction requiring Mg²⁺. The identity of the diphosphatidylglycerol was
established by thin-layer chromatography and mild alkaline hydrolysis. Diphosphatidylglycerol
formation from [³H]phosphatidylglycerol was shown to occur only in the
presence of CDP-diglyceride. The rate of diphosphatidylglycerol formation appears
to be quite slow in mitochondria and may explain why it was not previously observed.
Evidence is presented which eliminates the possibility of a bacterial contribution to
the biosynthetic process observed
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