Skip to main content
Article thumbnail
Location of Repository

Biosynthesis of cardiolipin in liver mitochondria

By K.Y. Hostetler, H. van den Bosch and L.L.M. van Deenen


Diphosphatidylglycerol (cardiolipin) biosynthesis from CDP-diglyceride and\ud sn-glycerol-3-phosphate has been demonstrated in a preparation of mitochondria from\ud rat liver in a reaction requiring Mg²⁺. The identity of the diphosphatidylglycerol was\ud established by thin-layer chromatography and mild alkaline hydrolysis. Diphosphatidylglycerol\ud formation from [³H]phosphatidylglycerol was shown to occur only in the\ud presence of CDP-diglyceride. The rate of diphosphatidylglycerol formation appears\ud to be quite slow in mitochondria and may explain why it was not previously observed.\ud Evidence is presented which eliminates the possibility of a bacterial contribution to\ud the biosynthetic process observed

Topics: Biologie
Year: 1971
OAI identifier:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.