Skip to main content
Article thumbnail
Location of Repository

Cyclic 3′,5′-AMP phosphodiesterase of Saccharomyces carlsbergensis Inhibition by adenosine 5′-triphosphate, inorganic pyrophosphate and inorganic polyphosphate

By G.A.G. Speziali and R. van Wijk


1. 1. Cyclic 3′,5′-AMP phosphodiesterase activity can be demonstrated in Saccharomyces carlsbergensis by measuring the 5′-AMP formation from cyclic 3′,5′-AMP.\ud \ud \ud \ud 2. 2. Enzymic activity was optimal at pH 8.5 and shows a 2-fold stimulation in the presence of 4 mM Mn2+; Mg2+, Ca2+ and EDTA hardly show any effect.\ud \ud \ud \ud 3. 3. ATP, inorganic polyphosphate and pyrophosphate are effective inhibitors of the phosphodiesterase. The nature of these inhibitions was found to be of the mixed type.\ud \ud \ud \ud 4. 4. The possible physiological significance of this inhibition is discussed

Topics: Scheikunde
Year: 1971
OAI identifier:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.