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Clastogenic effects of biosynthetic human growth hormone in Snell dwarf mice and CHO cells in vitro

By P.P.W. van Buul and S. van Buul-Offers


Treatment of Snell dwarf mice with high concentrations of human growth hormone from pituitaries as well as of bacterial origin, significantly increased the frequencies of chromosomal aberrations in bone-marrow cells, as measured by the micronucleus test. In vitro treatment of Chinese hamster ovary (CHO) cells with the two types of hormone likewise induced structural chromosomal aberrations

Topics: Geneeskunde
Year: 1984
OAI identifier: oai:dspace.library.uu.nl:1874/24105
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