Expression of MHC genes in adenovirus-tranformed cells

Abstract

Class I MHC gene expression is drastically reduced in Ad12-, but not in Ad5-transformed primary cells of three different rodent species. Here we demonstrate that class I expression in Ad12-transformed primary Baby Rat Kidney cells can be reactivated by AdS. We also show that class I gene expression is switched off only when primary cells were transformed by Ad12, but not when established cell lines were transformed