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Expression of MHC genes in adenovirus-tranformed cells

By R.T.M.J. Vaessen, R.A. Bernards, B.A. Oostra, A. Houweling, A.G. Jochemsen, J.L. Bos and A.J. van der Eb


Class I MHC gene expression is drastically reduced in\ud Ad12-, but not in Ad5-transformed primary cells of three\ud different rodent species. Here we demonstrate that class I\ud expression in Ad12-transformed primary Baby Rat Kidney\ud cells can be reactivated by AdS.\ud We also show that class I gene expression is switched\ud off only when primary cells were transformed by Ad12, but\ud not when established cell lines were transformed

Topics: Biologie
Year: 1984
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