Gruvberger et al. postulate, in their commentary published
in this issue of Breast Cancer Research, that our
“prognostic gene set may not be broadly applicable to
other breast tumor cohorts”, and they suggest that “it may
be important to define prognostic expression profiles separately
in estrogen receptor (ER) positive and negative
tumors”. This is based on two observations derived from
our gene expression profiling data in breast cancer: the
overlap between reporter genes for prognosis and ER
status, and Gruvberger et al.’s inability to confirm the
prognosis prediction using a nonoptimal selection of 58 of
our 231 prognosis reporter genes
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