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Expression profiling predicts outcome in breast cancer

By R.A. Bernards, L.J. van ’t Veer, H. Dai, M.J. van de Vijver, Y.D. He, A.A.M. Hart and S.H. Friend

Abstract

Gruvberger et al. postulate, in their commentary published\ud in this issue of Breast Cancer Research, that our\ud “prognostic gene set may not be broadly applicable to\ud other breast tumor cohorts”, and they suggest that “it may\ud be important to define prognostic expression profiles separately\ud in estrogen receptor (ER) positive and negative\ud tumors”. This is based on two observations derived from\ud our gene expression profiling data in breast cancer: the\ud overlap between reporter genes for prognosis and ER\ud status, and Gruvberger et al.’s inability to confirm the\ud prognosis prediction using a nonoptimal selection of 58 of\ud our 231 prognosis reporter genes

Topics: Biologie
Year: 2003
OAI identifier: oai:dspace.library.uu.nl:1874/20956
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