This thesis concerns extrapyramidal syndromes (EPS) and is divided into three parts because each part has its own study design. The focus of part 1 is on the epidemiology of the EPS tardive dyskinesia, tardive dystonia, parkinsonism, and akathisia. Part 2 focuses on tardive dystonia. It starts with a review of this syndrome and then reports the results of a clinical trial with clozapine. Part 3 opens with a review of acute dystonia and then the results are given of a prospective study that investigated whether the use of cocaine is a risk factor for neuroleptic induced acute dystonia
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