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A light and electron microscopical study of B-50 (GAP43) in human intramuscular nerve and neuromuscular junctions during development

By W.H. Gispen, L.F.G.M. Hesselmans, F.G.I. Jennekens, C.J.M. van den Oord, A.B. Oestreicher and H. Veldman


The growth associated protein B-50 (GAP-43) is demonstrated in human intramuscular nerves and neuromuscular junctions by light microscopy and electron microscopy. Nearly all fetal endplates are shown to be immunoreactive for B-50. The percentage of B50 positive endplates decreases significantly during the peri- and neonatal period, but in children and adults a low percentage of B50 positive endplates remains present. These data indicate that also in the human peripheral nervous system the expression of B-50 is developmentally regulated

Topics: Geneeskunde, GAP-43, phosphoprotein B-50, intramuscular nerve, neuromuscular junction, human development
Year: 1989
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