Default mode network functional connectivity altered in failed back surgery syndrome

Abstract

The purpose of this study was to identify alterations in the default mode network of failed back surgery syndrome patients as compared to healthy subjects. Resting state functional magnetic resonance imaging was conducted at 3 Tesla and data were analyzed with an independent component analysis. Results indicate an overall reduced functional connectivity of the default mode network and recruitment of additional pain modulation brain regions, including dorsolateral prefrontal cortex, insula, and additional sensory motor integration brain regions, including precentral and postcentral gyri, for failed back surgery syndrome patients. Perspective: This article presents alterations in the default mode network of chronic low back pain patients with failed back surgery syndrome as compared to healthy participants. \ua9 2013 by the American Pain Society.Peer reviewed: YesNRC publication: Ye