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Investigating the effect of photodynamic therapy on nerves using tissue engineered culture models

By K.E. Wright, E Liniker, A.J. MacRobert, R.A. Brown, M.J. Saffrey and J.B. Phillips


Introduction: Photodynamic therapy (PDT) shows potential as an effective treatment for prostate cancer. Clinical observations indicate that this approach causes fewer nerve damage related side-effects than conventional treatments. The aim here is to investigate the effect of PDT on nerve tissue using engineered 3-dimensional cell culture models. Initial experiments focussed on establishing photosensitiser localisation in neurones and Schwann cells, then developing a model for simulating nerve PDT in culture

Year: 2006
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Provided by: Open Research Online

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