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Factors influencing plasma renin and angiotensin II in the conscious pregnant ewe and its foetus

By Fiona Broughton Pipkin, Eugenie R. Lumbers and Joan C. Mott


1. Plasma renin (measured in the presence of additional substrate) was significantly higher (10·7 ± 1·1 S.E. of mean ng/ml.hr) in foetal lambs of 111-144 days gestation age (full term 147 days) than in their mothers (1·5 ± 0·2 ng/ml.hr S.E. of mean, P < 0·001) but plasma angiotensin II concentrations were in the same range (ewe 47·3 ± 6·6 S.E. of mean, foetus 47·4 ± 14·1 S.E. of mean pg/ml.). The endogenous velocity of renin production by foetal plasma was also greater than that of maternal plasma

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