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A non-linear voltage dependent charge movement in frog skeletal muscle.

By W K Chandler, R F Rakowski and M F Schneider


1. Voltage-clamp experiments were carried out using the three microelectrode technique. Using this method membrane current density at V1 is proportional to deltaV( = V2 - V1) where V1 and V2 are voltages at distances 1 and 21 from the end of a fibre. Voltage dependent sodium currents were blocked by tetrodotoxin, potassium by tetraethylammonium ions and rubidium. Contraction was blocked by adding sucrose, 467 mM. 2. The current deltaV (control) associated with a positive voltage step from a hyperpolarized conditioning voltage to the holding potential, -80 mV, showed two components, a capacitative transient which decayed rapidly and a maintained steady level..

Topics: Research Article
OAI identifier: oai:pubmedcentral.nih.gov:1309194
Provided by: PubMed Central
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