Photoaffinity Labeling of Small-Molecule-Binding Proteins by DNA-Templated Chemistry

Li, G; Liu, Ying; Liu, Yu; Chen, L; Wu, S; Liu, Yang; Li, X

research article

oai:hub.hku.hk:10722/221120

Photoaffinity Labeling of Small-Molecule-Binding Proteins by DNA-Templated Chemistry

Authors: G Li
Ying Liu
Yu Liu
L Chen
S Wu
Yang Liu
X Li
Publication date: 1 January 2013
Publisher: Germany
Doi

Abstract

DNA-templated affinity labeling: Accurate characterization of small-molecule (SM)-protein interactions is one of the most important but also very challenging tasks in chemical biology and drug discovery. A novel method named DNA-programmed photoaffinity labeling is reported. The introduction of DNA encoding and template effect enable multiplexed protein labeling by multiple probes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

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oai:hub.hku.hk:10722/221120

Last time updated on 01/06/2016

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