research article
Mu opioid receptor-containing neurons mediate electroacupuncture-produced anti-hyperalgesia in rats with hind paw inflammation
Abstract
Previous studies showed that electroacupuncture (EA) significantly attenuates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat model. The present study demonstrates that pretreatment with Derm-sap, a selective toxin for neurons that contain mu opioid receptor (MOR), specifically decreases MOR and blocks EA anti-hyperalgesia. These data suggest that spinal MOR-containing neurons are involved in the processes by which EA produces anti-hyperalgesia. © 2005 Elsevier B.V. All rights reserved.link_to_subscribed_fulltex- Article
- Acupuncture
- Dermorphin-saporin
- Hyperalgesia
- Pain
- Rat
- Spinal cord
- Analysis Of Variance
- Animals
- Blotting, Western - Methods
- Electroacupuncture - Methods
- Freund's Adjuvant - Adverse Effects
- Hindlimb - Drug Effects - Innervation
- Hyperalgesia - Etiology - Therapy
- Immunohistochemistry - Methods
- Inflammation - Chemically Induced - Complications
- Lectins - Metabolism
- Male
- N-Glycosyl Hydrolases
- Neurons - Metabolism
- Opioid Peptides
- Pain Measurement - Methods
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Reaction Time - Drug Effects
- Receptors, Opioid, Delta - Metabolism
- Receptors, Opioid, Mu - Metabolism
- Recombinant Fusion Proteins - Pharmacology
- Ribosome Inactivating Proteins, Type 1
- Skin - Drug Effects - Innervation
- Spinal Cord - Cytology - Drug Effects - Metabolism
- Substance P - Metabolism
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This paper was published in HKU Scholars Hub.
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