The phosphine-catalyzed alkyne to 1,3-diene isomerization reaction

Abstract

The alkyne to 1,3-diene isomerization reaction is a process in which a nucleophilic phosphine catalyst promotes the rearrangement of an electron-withdrawing group activated alkyne to the corresponding conjugated diene. The origin, mechanism, development, and application of this organocatalytic and stereoselective reaction in the synthesis of complex organic molecules are reviewed. © Georg Thieme Verlag Stuttgart.link_to_subscribed_fulltex