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Volume-regulatory K+ efflux during concentrative uptake of alanine in isolated rat hepatocytes.

By L O Kristensen and M Folke


Changes in cell volume and 42K+ efflux associated with concentrative alanine uptake were studied in isolated rat hepatocytes suspended in Krebs-Ringer bicarbonate buffer. After addition of 10 mM-alanine, cellular water volume increased by 15% and the rate constant of 42K+ efflux by 250%. Alanine-induced 42K+ efflux was abolished by quinine and was strongly decreased when the cell-volume increase was counteracted by sucrose. The results suggest that K+ efflux during alanine uptake is implicated in a volume-regulatory response

Topics: Research Article
Year: 1984
DOI identifier: 10.1042/bj2210265
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Provided by: PubMed Central
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