Article thumbnail
Location of Repository

Hypothesis: the aplastic crisis of hereditary spherocytosis is due to a single transmissible agent.

By P P Mortimer


Aplastic crisis in sickle cell anaemia has been associated with infection by a serum parvovirus-like virus (SPLV). Reports of outbreaks of these crises in hereditary spherocytosis (HS) were investigated to see if the data were consistent with a single agent such as SPLV being their cause. The age distribution of the cases and the pattern of spread were compatible with an infectious aetiology. The symptoms and duration of the cases, and the intervals between them, were sufficiently uniform to indicate that they were caused wholly or predominantly by a single agent with an incubation period of about nine days. There were close similarities between these illnesses and recognised cases of SPLV infection. It is concluded that SPLV is probably the main cause of aplastic crisis in HS

Topics: Research Article
Year: 1983
DOI identifier: 10.1136/jcp.36.4.445
OAI identifier:
Provided by: PubMed Central
Sorry, our data provider has not provided any external links therefore we are unable to provide a link to the full text.

Suggested articles

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.