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Diamond-Blackfan syndrome and neutropenia.

By K P Schofield and D I Evans

Abstract

Neutropenia is a rare complication of Diamond-Blackfan syndrome (congenital hypoplastic anaemia). Three patients are reported: all had neutropenia as well as anaemia, and to investigate the cause of the neutropenia culture of bone marrow for granulocyte-macrophage colony forming cells (GMCFCs) was performed. Two cases had a low incidence of GMCFCs, but the third case had a high incidence. These findings suggest that myeloid precursors can be abnormal in Diamond-Blackfan syndrome and that the mechanism of neutropenia may, like that of anaemia, vary from patient to patient

Topics: Research Article
Year: 1991
DOI identifier: 10.1136/jcp.44.9.742
OAI identifier: oai:pubmedcentral.nih.gov:496720
Provided by: PubMed Central
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