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Abnormal haemoglobin electrophoresis caused by BW 12C.

By F van Rhee, I Ware and T Littlewood

Abstract

BW 12C, a substituted benzaldehyde, stabilises haemoglobin in the oxy-conformation and has attracted interest as an anti-sickling agent. The drug causes a left shift in the oxygen saturation curve and may induce tumour anoxia and enhance the effect of cytotoxic drugs. During clinical trials in patients with cancer abnormal bands on haemoglobin electrophoretic strips were observed. This made correct diagnosis of abnormal haemoglobins impossible. Solubility tests for sickling disorders (Itano) also proved unreliable

Topics: Research Article
Year: 1992
DOI identifier: 10.1136/jcp.45.10.930
OAI identifier: oai:pubmedcentral.nih.gov:495072
Provided by: PubMed Central
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