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Creutzfeldt-Jakob disease treated with amantidine: A report of two cases

By W. L. Sanders and T. L. Dunn


The treatment of two cases of Creutzfeldt-Jakob disease with amantidine is described. The first case made a remarkable initial improvement which was sustained for two months, but then deteriorated and died. Histological examination of the brain showed changes consistent with early Creutzfeldt-Jakob disease. The second case which was clinically one of Creutzfeldt-Jakob disease has now been followed for 30 months since the start of treatment and appears to be cured. It is considered that amantidine has a definite effect in this disease and it is suggested that its mode of action, though unknown, is more likely to be metabolic than antiviral

Topics: Articles
Year: 1973
DOI identifier: 10.1136/jnnp.36.4.581
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Provided by: PubMed Central
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