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Multicentre post-infarction trial of propranolol in 49 hospitals in the United Kingdom, Italy, and Yugoslavia.

By N S Baber, D W Evans, G Howitt, M Thomas, T Wilson, J A Lewis, P M Dawes, K Handler and R Tuson

Abstract

A multicentre study of survivors of an anterior myocardial infarction is reported. The trial consisted of 720 patients and was a double-blind, placebo-controlled study with propranolol 40 mg three times a day. Trial entry was at two to 14 days (mean 8.5 days) and follow-up at one, three, and in most centres, six and nine months. The trial was designed to detect a 50 per cent reduction in mortality and this was not shown. The non-fatal reinfarction rate was similar in both groups. Subgroup analysis identified several prognostic risk factors for death, none of which interacted with treatment

Topics: Research Article
Year: 1980
DOI identifier: 10.1136/hrt.44.1.96
OAI identifier: oai:pubmedcentral.nih.gov:482366
Provided by: PubMed Central
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