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Epstein-Barr Virus Latent Membrane Protein LMP-2A Is Sufficient for Transactivation of the Human Endogenous Retrovirus HERV-K18 Superantigen

By Natalie Sutkowski, Gang Chen, German Calderon and Brigitte T. Huber


Superantigens are microbial proteins that strongly stimulate T cells. We described previously that the Epstein-Barr virus (EBV) transactivates a superantigen encoded by the human endogenous retrovirus, HERV-K18. We now report that the transactivation is dependent upon the EBV latent cycle proteins. Moreover, LMP-2A is sufficient for induction of HERV-K18 superantigen activity

Topics: Virus-Cell Interactions
Publisher: American Society for Microbiology
Year: 2004
DOI identifier: 10.1128/JVI.78.14.7852-7860.2004
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Provided by: PubMed Central
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