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Clinical and Bacteriological Evaluation of Netilmicin in Gram-Negative Infections

By J. Klastersky, F. Meunier-Carpentier, L. Coppens-Kahan, D. Daneau and J. M. Prevost

Abstract

A preliminary study was conducted with netilmicin, a new aminoglycoside antibiotic. Its effectiveness was evaluated in vitro against 546 strains of Enterobacteriaceae and Pseudomonas aeruginosa isolated from clinical material. Its effectiveness against gentamicin-susceptible strains was roughly similar to that of gentamicin and other newer aminoglycoside antibiotics. Cross-resistance to netilmicin was found in 9 of 44 gentamicin-resistant strains. A favorable clinical response was observed in 70% of the patients treated with a dose of netilmicin ranging from 4.5 to 7.5 mg/kg. However, the appearance of granular casts was seen in 7 of 10 patients receiving the higher dosage of netilmicin (7.5 mg/kg) and a rise in blood urea nitrogen or serum creatinine levels was observed in 5 of these patients

Topics: Pharmacology and Therapeutics
Year: 1977
DOI identifier: 10.1128/aac.12.4.503
OAI identifier: oai:pubmedcentral.nih.gov:429954
Provided by: PubMed Central
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