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Correlation of Resistance to Proflavine and Penicillin in Escherichia coli

By Robin C. McKellar, Colin N. McKenzie and Donn J. Kushner


A number of proflavine (PF)-resistant mutants of Escherichia coli B were also resistant to penicillin and cephalothin. Mutants resistant to 1.0 mM PF were 10 times more penicillin resistant than were the PF-susceptible, wild-type cells. Single-step mutants selected for resistance to either PF or penicillin were also resistant to the other drug. None of the resistant mutants tested possessed β-lactamase activity. These results suggest that resistance to PF and penicillin in E. coli B may be due to permeability changes in the cell envelope

Topics: Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Year: 1976
DOI identifier: 10.1128/aac.10.4.765
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Provided by: PubMed Central
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