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Artificial Elimination of Drug Resistance from Group A Beta-Hemolytic Streptococci

By Masataka Nakae, Matsuhisa Inoue and Susumu Mitsuhashi


Ten strains of beta-hemolytic streptococci were tested for elimination of resistance to macrolide antibiotics, tetracycline, and chloramphenicol. Six of the strains lost resistance after cultivation at 41 C or addition of acriflavine (0.2 μg/ml). These results suggest that determinants governing resistance to these antibiotics are located on extrachromosomal genetic elements (plasmids) that are widely distributed in streptococci

Topics: Articles
Year: 1975
DOI identifier: 10.1128/aac.7.5.719
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Provided by: PubMed Central
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