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T-type calcium channels are involved in hypoxic pulmonary hypertension

By Marc Chevalier, Guillaume Gilbert, Etienne Roux, Philipe Lory, Roger Marthan, Jean-Pierre Savineau and Jean-François Quignard

Abstract

Pulmonary hypertension (PH) is the main disease of pulmonary circulation. Alteration in calcium homeostasis in pulmonary artery smooth muscle cells (PASMCs) is recognized as a key feature in PH. The present study was undertaken to investigate the involvement of T-type voltage-gated calcium channels (T-VGCCs) in the control of the pulmonary vascular tone and thereby in the development of PH.status: publishe

Topics: Animals, Anoxia, Benzeneacetamides, Calcium, Calcium Channels, T-Type, Disease Models, Animal, Hypertension, Pulmonary, Male, Membrane Potentials, Mice, Mice, Knockout, Muscle, Smooth, Vascular, Myocytes, Smooth Muscle, Pulmonary Artery, Pyridines, Rats, Wistar
Publisher: British Medical Association
Year: 2014
DOI identifier: 10.1093/cvr/cvu166
OAI identifier: oai:lirias.kuleuven.be:123456789/529355
Provided by: Lirias
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