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DNA Modification Methylase Activity of Escherichia coli Restriction Endonucleases K and P

By Allan Haberman, Janet Heywood and Matthew Meselson


The highly purified restriction endonucleases of E. coli K and coliphage P1 transfer methyl groups from S-adenosylmethionine to adenine residues of unmodified DNA. Incubation of unmodified DNA with endonucleases K or P and S-adenosylmethionine renders the DNA resistant to restriction. The enzymes, therefore, have both restriction endonuclease and modification methylase activities

Topics: Biological Sciences: Biochemistry
Year: 1972
DOI identifier: 10.1073/pnas.69.11.3138
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Provided by: PubMed Central
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