Evaluation of the ability of an organic derivative of ruthenium(II) to reinforce the cytotoxicity of fast neutron against malignant cells in culture

Leyva, L.; Malek, F.; Benzina, S.; Denis, Jeanne; Gueulette, John; Dufour, Philippe; Gaiddon, C.; Loeffler, J. P.; Sirlin, C.; Pfeffer, M.; Bischoff, P.

oai:dial.uclouvain.be:boreal:36732

Evaluation of the ability of an organic derivative of ruthenium(II) to reinforce the cytotoxicity of fast neutron against malignant cells in culture

Authors: L. Leyva
F. Malek
S. Benzina
Jeanne Denis
John Gueulette
Philippe Dufour
C. Gaiddon
J. P. Loeffler
C. Sirlin
M. Pfeffer
P. Bischoff
Publication date: 1 January 2008
Publisher: Bentham Science Publ Ltd
Doi

Abstract

The effect of combining RDC-11 (a new ruthenium organometallic complex) and fast neutrons (high-LET radiations) has been evaluated in RDM4 and U-87 tumor cell lines. After co-treatment, a substantial reduction of cell growth was recorded, which appears not to be correlated with the induction of apoptosis

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Last time updated on 14/05/2016

This paper was published in DIAL UCLouvain.

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