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A Variable Region Subclass of Heavy Chains Common to Immunoglobulins G, A, and M and Characterized by an Unblocked Amino-Terminal Residue*

By A. C. Wang, J. R. L. Pink, H. H. Fudenberg and J. Ohms


Heavy chains of IgG, IgA, and IgM classes of human immunoglobulins were compared by N-terminal residue determination and partial amino acid sequence analysis. A third subclass of the variable region of heavy chains was observed; an unblocked glutamic acid as the N-terminal residue is characteristic of this subclass. Our results indicated that the heavy chain variable region subclasses are not class specific, and that a given heavy chain variable region may be found in association with constant regions for μ-chains, α-chains, or γ-chains of various subclasses

Topics: Biological Sciences: Immunology
Year: 1970
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Provided by: PubMed Central
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