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ELECTRON-TRANSPORT COMPONENTS OF STREPTOMYCIN-DEPENDENT ESCHERICHIA COLI

By P. D. Bragg and W. J. Polglase

Abstract

Bragg, P. D. (University of British Columbia, Vancouver, B. C, Canada) and W. J. Polglase. Electron-transport components of streptomycin-dependent Escherichia coli. J. Bacteriol. 86:544–547. 1963.—When a streptomycin-dependent strain of Escherichia coli was grown in antibiotic-free medium, the resulting streptomycin-depleted cells were found to contain relatively large amounts of vitamin K2. Cytochromes a1 and a2 were absent from depleted cells, and these cells metabolized glucose with the accumulation of lactic acid. Depleted cells were normal in their content of coenzyme Q8, total flavine, and cytochrome b. Growth of depleted cells on medium containing dihydrostreptomycin restored their ability to metabolize lactic acid concomitantly with a decrease in vitamin K2 to a normal level, and with the formation of cytochromes a1 and a2. It is concluded that streptomycin (or dihydrostreptomycin) is required by dependent E. coli for maintenance of the integrity of the electron-transport system

Topics: Articles
Year: 1963
OAI identifier: oai:pubmedcentral.nih.gov:278469
Provided by: PubMed Central
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