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Evidence that Clostridium perfringens theta-toxin induces colloid-osmotic lysis of erythrocytes.

By R W Harris, P J Sims and R K Tweten


Clostridium perfringens theta-toxin was shown to lyse target erythrocytes by a colloid-osmotic mechanism. Analysis showed the onset of lysis of erythrocytes by theta-toxin could be temporarily stabilized with 0.3 M sucrose. Flow cytometry analysis of the size distribution of theta-toxin-treated erythrocytes showed swelling of the erythrocytes prior to lysis

Topics: Research Article
Year: 1991
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Provided by: PubMed Central
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