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An enhanced murine model for studies of Serpulina (Treponema) hyodysenteriae pathogenesis.

By S K Nibbelink and M J Wannemuehler


A defined diet was used to increase the susceptibility of mice to Serpulina hyodysenteriae. BALB/cByJ, C3H/HeN, and C3H/HeJ mice, when fed the defined diet 7 to 14 days prior to and throughout the challenge period, consistently showed higher incidences of disease than mice maintained on normal rodent chow. The use of this defined diet will increase the consistency of in vivo studies following infection with S. hyodysenteriae in the mouse model

Topics: Research Article
Year: 1992
OAI identifier: oai:pubmedcentral.nih.gov:257332
Provided by: PubMed Central
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