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Murine retroviral restriction genes Fv-4 and Akvr-1 are alleles of a single locus.

By S J O'Brien, E J Berman, J D Estes and M B Gardner


The two murine retroviral restriction genes, Fv-4 and Akvr-1, are very similar in their effects, distributions, ranges of action, and phenotypes. Akvr-1 has been shown to segregate independently in backcrosses with a variety of retroviral restriction loci, including Fv-1, Fv-2, Ril-1, and Ril-2. An allelism test cross of FRG (Fv-4R) X LCRR (Akvr-1R) hybrids mated to AKR mice failed to produce any viremic offspring. These results suggested that Akvr-1R and Fv-4R are alleles of a single locus, Fv-4, on mouse chromosome 12

Topics: Research Article
Year: 1983
OAI identifier: oai:pubmedcentral.nih.gov:255307
Provided by: PubMed Central
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