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A Bipartite Late-Budding Domain in Human Immunodeficiency Virus Type 1

By Juan Martin-Serrano and Paul D. Bieniasz


Human immunodeficiency virus type 1 (HIV-1) encodes a PTAP motif within the p6 domain of Gag that recruits Tsg101 and associated factors to facilitate virion budding. In this study, we use trans-complementation assays to demonstrate that the PTAP motif acts synergistically with additional p6 sequences to mediate the formation of infectious extracellular HIV-1 virions. These studies suggest that Tsg101 recruitment is necessary but not sufficient to account for late-budding activity exhibited by HIV-1 p6

Topics: Structure and Assembly
Publisher: American Society for Microbiology
Year: 2003
DOI identifier: 10.1128/JVI.77.22.12373-12377.2003
OAI identifier:
Provided by: PubMed Central
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