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Antifungal Combinations against Candida albicans Biofilms In Vitro

By Stefano P. Bachmann, Gordon Ramage, Kacy VandeWalle, Thomas F. Patterson, Brian L. Wickes and José L. López-Ribot

Abstract

Candida biofilms display increased resistance to most antifungal agents. We have evaluated the efficacy of combinations of fluconazole (FLC), amphotericin B, and caspofungin (CSP) against Candida albicans biofilms in vitro. Indifference was observed for all the combinations of paired antifungal agents when a checkerboard titration method was used. Time-kill experiments revealed an antagonistic effect of high FLC doses with CSP

Topics: Susceptibility
Publisher: American Society for Microbiology
Year: 2003
DOI identifier: 10.1128/AAC.47.11.3657-3659.2003
OAI identifier: oai:pubmedcentral.nih.gov:253764
Provided by: PubMed Central
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