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Interferon-regulated influenza virus resistance gene Mx is localized on mouse chromosome 16.

By P Staeheli, D Pravtcheva, L G Lundin, M Acklin, F Ruddle, J Lindenmann and O Haller

Abstract

Genomic Southern blots of mouse-hamster somatic cell hybrids were analyzed with a probe prepared from a cDNA encoding murine Mx protein, the product of the interferon-regulated influenza virus resistance allele Mx+. Results of this analysis indicate that the Mx gene is located on mouse chromosome 16. In appropriate backcross mice, no linkage was observed between Mx and md, a marker previously mapped close to the centromere of chromosome 16, suggesting a more distal localization of Mx

Topics: Research Article
Year: 1986
OAI identifier: oai:pubmedcentral.nih.gov:253008
Provided by: PubMed Central
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