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Specific lysis of varicella zoster virus-infected B lymphoblasts by human T cells.

By A R Hayward, O Pontesilli, M Herberger, M Laszlo and M Levin


Epstein-Barr virus-transformed human B cells expressed cell surface varicella-zoster virus (VZV) antigens after superinfection with VZV although they did not form infectious centers in a plaque assay. The VZV-superinfected cells were lysed by autologous VZV-stimulated T-cell lines and their derivative clones. The effector cells were specific for VZV and an HLA DR antigen and were T4+. The specificity of lysis of Epstein-Barr virus-transformed, VZV-superinfected targets by prestimulated mononuclear cells in this system contrasted with the unrestricted lysis seen when the targets were VZV-infected fibroblasts

Topics: Research Article
Year: 1986
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Provided by: PubMed Central
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