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Regulator Gene Controlling Enzymes Concerned in Tyrosine Biosynthesis in Escherichia coli

By B. J. Wallace and James Pittard


Mutants of Escherichia coli K-12 have been isolated in which several enzymes concerned with tyrosine biosynthesis are derepressed. These mutants were obtained from a parent strain possessing only a single 3-deoxy-d-arabinoheptulosonic acid-7-phosphate (DAHP) synthetase isoenzyme, DAHP synthetase (tyr), by selecting for resistance to the tyrosine analogue, 4-aminophenylalanine. The mutation responsible for this derepression has been mapped and the gene, which is not closely linked to aroF and tyrA, has been designated tyrR

Topics: Genetics Molecular Biology
Year: 1969
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Provided by: PubMed Central
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