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Tales from the crypt

By Eric A. Schon

Abstract

Intestinal colonic crypts are derived from a stem cell population located at the base of each crypt. A new analysis of mitochondrial function and of the rates of mitochondrial DNA (mtDNA) mutation in individual crypts shows that mtDNA mutations arise in stem cells — and at a surprisingly high frequency. Because crypts turn over extremely rapidly (about once per week), somatic mtDNA mutations can “take over the system” and even become homoplasmic, in a manner similar to what has been shown to occur in tumors

Topics: Commentary
Publisher: American Society for Clinical Investigation
Year: 2003
DOI identifier: 10.1172/JCI200320249
OAI identifier: oai:pubmedcentral.nih.gov:233116
Provided by: PubMed Central
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