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COMPLEX MITOCHONDRIAL DNA IN LEUKEMIC AND NORMAL HUMAN MYELOID CELLS*

By David A. Clayton and Jerome Vinograd

Abstract

Mitochondrial DNA's from the peripheral blood of 14 patients with granulocytic leukemia contained a circular dimer form. No such structure could be found in M DNA's from three patients with nonmalignant proliferations of granulocytes. The frequency of the circular dimer form is reduced upon treatment with antileukemic drugs. The above results suggest that a significant relation exists between the formation and presence of the circular dimer M DNA form and granulocytic leukemia in man

Topics: Biological Sciences: Medical Sciences
Year: 1969
OAI identifier: oai:pubmedcentral.nih.gov:223617
Provided by: PubMed Central
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