Dimeric IVIG contains natural anti-Siglec-9 autoantibodies and their anti-idiotypes

Schaub, A; von Gunten, S; Vogel, M; Wymann, S; Rüegsegger, M; Stadler, B M; Spycher, M; Simon, H-U; Miescher, S

research article review

oai:boris.unibe.ch:2665

Dimeric IVIG contains natural anti-Siglec-9 autoantibodies and their anti-idiotypes

Authors: A Schaub
S von Gunten
M Vogel
S Wymann
M Rüegsegger
B M Stadler
M Spycher
H-U Simon
S Miescher
Publication date: 1 January 2011
Publisher: Wiley-Blackwell
Doi

Abstract

Intravenous immunoglobulin (IVIG) preparations are increasingly used for the treatment of autoimmune and chronic inflammatory diseases. Naturally occurring autoantibodies against Siglec-9 and Fas are thought to contribute to the anti-inflammatory effects of IVIG via cell death regulation of leukocytes and tissue cells. Dimeric IVIG fractions are suspected to contain idiotypic (Id)-anti-idiotypic complexes of antibodies, which might also include anti-Siglec-9 and anti-Fas autoantibodies

Similar works

Full text

BORIS Portal Bern Open Repository and Information System

oai:boris.unibe.ch:2665

Last time updated on 06/05/2016

This paper was published in BORIS Portal Bern Open Repository and Information System.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.