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Isolation of tetracenomycin C-nonproducing Streptomyces glaucescens mutants.

By H Motamedi, E Wendt-Pienkowski and C R Hutchinson


We analyzed the properties of tetracenomycin C (TcmC)-nonproducing mutants of Streptomyces glaucescens to establish the nature of pathway intermediates and to provide some information about the genetics of antitumor anthracycline antibiotic production. Using cosynthesis properties and metabolite accumulation data, we classified a collection of 34 TcmC-nonproducing strains into seven different groups. From this information, we deduced the positions of the tcm mutations in relation to a hypothetical TcmC biosynthetic pathway and suggest which pathway enzymes are affected by the different mutations

Topics: Research Article
Year: 1986
DOI identifier: 10.1128/jb.167.2.575-580.1986
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Provided by: PubMed Central
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