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Mutations in the delta subunit influence the assembly of F1F0 ATP synthase in Escherichia coli.

By A E Stack and B D Cain


Missense mutations affecting Asp-161 and Ser-163 in the delta subunit of F1F0 ATP synthase have been generated. Although most substitutions allowed substantial enzyme function, the delta Asp-161-->Pro substitution resulted in a loss of enzyme activity. The loss of activity was attributable to a structural failure altering assembly of the enzyme complex

Topics: Research Article
Year: 1994
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Provided by: PubMed Central
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