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Microbial Hydroxylation of 1,4-Cineole

By John P. N. Rosazza, James J. Steffens, F. Sima Sariaslani, Animesh Goswami, John M. Beale, Scot Reeg and Robert Chapman

Abstract

Microorganisms were examined for their potential to hydroxylate the oxygenated monoterpene 1,4-cineole. Using gas chromatography and thin-layer chromatography, screening experiments revealed that hydroxylation at position 2 was the most commonly observed microbial transformation reaction. In most microorganisms, the predominant alcohol metabolite was the 2-endo-alcohol isomer. Preparative-scale incubations were conducted in order to isolate and characterize microbial transformation products by comparison of proton nuclear magnetic resonance, mass spectrometry, and chromatography profiles with those of cineole standards. Streptomyces griseus yielded 8-hydroxy-1,4-cineole as the major hydroxylation product together with 2-exo- and 2-endo-hydroxy-1,4-cineoles

Topics: Physiology and Biotechnology
Year: 1987
OAI identifier: oai:pubmedcentral.nih.gov:204133
Provided by: PubMed Central
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