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Genetic contributions to generalized arousal of brain and behavior

By J. Garey, A. Goodwillie, J. Frohlich, M. Morgan, J.-A. Gustafsson, O. Smithies, K. S. Korach, S. Ogawa and D. W. Pfaff

Abstract

We have identified a generalized arousal component in the behavior of mice. Analyzed by mathematical/statistical approaches across experiments, investigators, and mouse populations, it accounts for about 1/3 of the variance in arousal-related measures. Knockout of the gene coding for the classical estrogen receptor (ER-α), a ligand-activated transcription factor, greatly reduced arousal responses. In contrast, disrupting the gene for a likely gene duplication product, ER-β, did not have these effects. A combination of mathematical and genetic approaches to arousal in an experimentally tractable mammal opens up analysis of a CNS function of considerable theoretical and practical significance

Topics: Biological Sciences
Publisher: National Academy of Sciences
Year: 2003
DOI identifier: 10.1073/pnas.1633773100
OAI identifier: oai:pubmedcentral.nih.gov:196919
Provided by: PubMed Central
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