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The min locus, which confers topological specificity to cell division, is not involved in its coupling with nucleoid separation.

By M Dassain and J P Bouché

Abstract

In Escherichia coli, nucleoid separation and cell constriction remain tightly linked when division is retarded by altering the level of synthesis of the protein FtsZ. In this study, we have examined the role of the min locus, which is responsible for the inactivation of polar division sites, in the partition-septation coupling mechanism. We conclude that the coupling persists in a delta min strain and that its timing relative to replication remains dependent on the level of FtsZ synthesis. We suggest that the retarded nucleoid segregation observed in min mutants is the result of this coupling in cells with a perturbed pattern of nonpolar divisions

Topics: Research Article
Year: 1994
DOI identifier: 10.1128/jb.176.19.6143-6145.1994
OAI identifier: oai:pubmedcentral.nih.gov:196837
Provided by: PubMed Central
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