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Distribution of ciprofloxacin in ascitic fluid following administration of a single oral dose of 750 milligrams.

By M Dan, T Zuabi, C Quassem and H H Rotmensch


The penetration of ciprofloxacin into the ascitic fluid of eight patients was studied. Serum and ascitic fluid samples were obtained before and at 1, 2, 3, 6, and 12 h following administration of a single oral dose of 750 mg. Peak levels (mean +/- standard deviation) were 4.0 +/- 0.7 micrograms/ml in serum and 2.6 +/- 0.6 micrograms/ml in ascitic fluid; the areas under the curve (0 to 12 h) were 29.1 +/- 6.5 micrograms.h/ml in serum and 20.7 +/- 5.0 micrograms.h/ml in ascitic fluid. The concentrations that were achieved are well above the MICs of ciprofloxacin for the members of the family Enterobacteriaceae that cause spontaneous bacterial peritonitis

Topics: Research Article
Year: 1992
DOI identifier: 10.1128/aac.36.3.677
OAI identifier:
Provided by: PubMed Central
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