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Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential.

By K Suomalainen, T Sorsa, L M Golub, N Ramamurthy, H M Lee, V J Uitto, H Saari and Y T Konttinen


The concentrations of doxycycline and 4-de-dimethylaminotetracycline required to inhibit 50% of collagenase activity were found to be 15 to 30 microM for human neutrophil and gingival crevicular fluid collagenases. Fibroblast collagenase was relatively resistant to inhibition by tetracyclines; the 50% inhibitory concentrations of doxycycline and 4-de-dimethylaminotetracycline were 280 and 510 microM, respectively

Topics: Research Article
Year: 1992
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Provided by: PubMed Central
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