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Long-Term Protective Immune Response Elicited by Vaccination with an Expression Genomic Library of Toxoplasma gondii

By Alberto Fachado, Alexandro Rodriguez, Judith Molina, Jaline C. Silvério, Ana P. M. P. Marino, Luzia M. O. Pinto, Sergio O. Angel, Juan F. Infante, Yara Traub-Cseko, Regina R. Amendoeira and Joseli Lannes-Vieira

Abstract

Immunization of BALB/c mice with an expression genomic library of Toxoplasma gondii induces a Th1-type immune response, with recognition of several T. gondii proteins (21 to 117 kDa) and long-term protective immunity against a lethal challenge. These results support further investigations to achieve a multicomponent anti-T. gondii DNA vaccine

Topics: Fungal and Parasitic Infections
Publisher: American Society for Microbiology
Year: 2003
DOI identifier: 10.1128/IAI.71.9.5407-5411.2003
OAI identifier: oai:pubmedcentral.nih.gov:187360
Provided by: PubMed Central
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